Jian-Xiong Chen Selected Research

Microvascular Rarefaction

1/2021	Sirtuin 3 Alleviates Diabetic Cardiomyopathy by Regulating TIGAR and Cardiomyocyte Metabolism.
1/2020	Sirtuin 3 is essential for hypertension-induced cardiac fibrosis via mediating pericyte transition.
10/2019	Sirtuin 3, Endothelial Metabolic Reprogramming, and Heart Failure With Preserved Ejection Fraction.
1/2019	Microvascular Rarefaction and Heart Failure With Preserved Ejection Fraction.
11/2017	Endothelial specific SIRT3 deletion impairs glycolysis and angiogenesis and causes diastolic dysfunction.
7/2016	Ablation of SIRT3 causes coronary microvascular dysfunction and impairs cardiac recovery post myocardial ischemia.
8/2015	High-fat diet induces cardiac remodelling and dysfunction: assessment of the role played by SIRT3 loss.

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Jian-Xiong Chen Research Topics

Disease

14	Fibrosis (Cirrhosis) 01/2022 - 02/2012
8	Hypoxia (Hypoxemia) 01/2022 - 04/2007
7	Heart Failure 01/2022 - 02/2014
7	Microvascular Rarefaction 01/2021 - 08/2015
5	Cardiovascular Diseases (Cardiovascular Disease) 11/2020 - 10/2006
5	Myocardial Ischemia (Ischemic Heart Diseases) 07/2016 - 04/2007
5	Myocardial Infarction 10/2015 - 06/2008
4	Cardiomegaly (Heart Hypertrophy) 11/2021 - 01/2019
4	Hypertrophy 01/2021 - 09/2012
4	Obesity 10/2019 - 12/2008
3	Inflammation (Inflammations) 01/2022 - 12/2008
3	Atherosclerosis 01/2021 - 10/2006
3	Diabetic Cardiomyopathies 01/2021 - 02/2014
3	Hypertension (High Blood Pressure) 01/2020 - 10/2006
3	Body Weight (Weight, Body) 01/2018 - 12/2012
2	Iron Overload 11/2020 - 01/2019
2	Infarction (Infarctions) 10/2015 - 09/2012
2	Spinocerebellar Ataxias (Spinocerebellar Ataxia) 01/2014 - 09/2012
1	Chronic Renal Insufficiency 01/2022
1	Cardiovascular Abnormalities 01/2021
1	Diabetes Mellitus 01/2021
1	Metabolic Diseases (Metabolic Disease) 01/2019
1	Vascular Remodeling 09/2016
1	Sepsis (Septicemia) 02/2016
1	Reperfusion Injury 09/2012
1	Corneal Neovascularization 07/2004

Drug/Important Bio-Agent (IBA)

16	Sirtuin 3IBA 01/2021 - 01/2013
8	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2021 - 10/2006
6	ApelinIBA 01/2020 - 09/2012
4	Angiotensin IIIBA 01/2022 - 01/2020
4	Glucose (Dextrose)FDA LinkGeneric 01/2022 - 08/2015
4	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 11/2021 - 01/2014
4	NADPH Oxidases (NAD(P)H oxidase)IBA 11/2020 - 04/2007
3	IronIBA 11/2020 - 01/2019
3	Prolyl Hydroxylases (Prolyl Hydroxylase)IBA 01/2020 - 09/2016
2	EnzymesIBA 01/2022 - 01/2019
2	CholesterolIBA 01/2021 - 03/2016
2	LipidsIBA 01/2018 - 03/2016
2	Mixed Function Oxygenases (Monooxygenases)IBA 01/2017 - 09/2016
2	Angiopoietin-2IBA 02/2012 - 09/2008
1	Transforming Growth Factor beta (TGF-beta)IBA 01/2022
1	PhosphofructokinasesIBA 01/2022
1	oxidized low density lipoproteinIBA 01/2020
1	Facilitative Glucose Transport Proteins (Glucose Transporter)IBA 01/2020
1	ConnectinIBA 10/2019
1	oil red OIBA 01/2018
1	Atrial Natriuretic Factor (ANF)IBA 01/2018
1	SirtuinsIBA 07/2016
1	NAD (NADH)IBA 07/2016
1	Caveolin 1IBA 03/2016
1	apelin-13 peptideIBA 09/2012
1	AngiotensinsIBA 09/2012
1	CXCR ReceptorsIBA 09/2012
1	LigandsIBA 09/2012
1	Toll-Like Receptors (Toll-Like Receptor)IBA 12/2008
1	erucylphosphocholineIBA 06/2008
1	AngiopoietinsIBA 06/2008
1	Streptozocin (Streptozotocin)FDA Link 06/2008
1	Mitogen-Activated Protein KinasesIBA 04/2007
1	Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA 04/2007
1	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 04/2007
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 07/2004

Therapy/Procedure

2	Ligation 07/2016 - 01/2013
1	Acupuncture Therapy 12/2012